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The orexin neurons innervate several areas of the brain that promote wakefulness and areas that suppress sleep, notably rapid eye movement (REM) sleep. The neurons that produce orexin are only found within the lateral hypothalamus and have a number of projections to brain areas that are responsible for arousal and lowering REM sleep, like locus coeruleus (LC), dorsal raphe (DR), periaqueductal grey (PAG), tuberomammillary nucleus (TMN), basal forebrain, and spinal cord. Modafinil was authorized by the FDA in 2007. This specific kind of drug additionally acts as a selective, weak, and typical dopamine reuptake inhibitor that not directly activates orexin neuropeptide launch as well as histamine from the tuberomammillary nucleus and lateral hypothalamus by unknown mechanisms. Two studies that had been finished in 1998 have independently identified neuropeptides (orexin A and orexin B) which might be solely produced within the lateral hypothalamus of the mind to be related to narcolepsy. Type 1 narcolepsy occurs as a result of the whole lack of all neurons referred to as hypocretin, which incorporates orexin. She was referred to the sleep clinic for evaluation of EDS that she had been experiencing for a number of years, associated with multiple awakenings through the night and latest episodes of a sudden lack of muscle tone within the neck.